目的:探讨丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的效果。方法:选取 2021 年 7 月—2023 年 6 月泉州市妇幼保健院·儿童医院收治的 72 例妊娠期肝内胆汁淤积症孕妇作为研究对象，按随机数表法将其分为对照组与研究组，各 36 例。对照组给予熊去氧胆酸治疗，研究组给予丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗。比较两组治疗效果、不良反应、血清总胆汁酸、血清γ-谷氨酰转移酶、皮肤瘙痒评分、新生儿不良结局及新生儿出生后 1 min、5 min Apgar评分。结果:研究组总有效率高于对照组，差异有统计学意义(P<0。05);两组不良反应总发生率比较，差异无统计学意义(P>0。05);治疗后，两组血清总胆汁酸、γ-谷氨酰转移酶水平及皮肤瘙痒评分较治疗前降低，且研究组低于对照组，差异有统计学意义(P<0。05);研究组新生儿不良结局总发生率低于对照组，新生儿出生后 1 min、5 min Apgar评分高于对照组，差异有统计学意义(P<0。05)。结论:丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症能有效控制病情，改善肝功能与新生儿结局，且具有良好的用药安全性。
Clinical Effect of Ademetionine Butanedisulfonate Combined with Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy
Objective:To explore the clinical effect of Ademetionine Butanedisulfonate combined with Ursodeoxycholic Acid in the treatment of intrahepatic cholestasis of pregnancy.Method:A total of 72 pregnant women with intrahepatic cholestasis of pregnancy who admitted to Quanzhou Women's and Children's Hospital from July 2021 to June 2023 were selected as the research objects,and they were divided into the control group and the study group according to the random number table method,with 36 cases in each group.The control group was treated with Ursodeoxycholic Acid,and the study group was treated with Ademetionine Butanedisulfonate combined with Ursodeoxycholic Acid.The therapeutic effect,adverse reactions,serum total bile acid,serum γ-glutamyl transferase,skin pruritus score,neonatal adverse outcome and neonatal Apgar score at 1 min and 5 min after birth were compared between two groups.Result:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05);after treatment,the levels of serum total bile acid,γ-glutamyl transferase and skin pruritus scores in two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05);the total incidence of neonatal adverse outcomes in the study group was lower than that in the control group,and the neonatal Apgar scores at 1 min and 5 min after birth were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Ademetionine Butanedisulfonate combined with Ursodeoxycholic Acid in the treatment of intrahepatic cholestasis of pregnancy can effectively control disease,improve liver function and neonatal outcome,and has good drug safety.
Intrahepatic cholestasis of pregnancyUrsodeoxycholic AcidAdemetionine Butanedisulfonate
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