Distribution and Drug Resistance of of Pathogenic Bacteria in Bile Bacterial Culture of Patients with Cholelithiasis Complicated with Biliary Tract Infection
Objective:To explore the distribution and drug resistance of of pathogenic bacteria in bile bacterial culture of patients with cholelithiasis complicated with biliary tract infection,providing a basis for the rational use of clinical antibiotics.Method:A total of 150 patients with cholelithiasis complicated with biliary tract infection who admitted to Longyan People's Hospital from January 2020 to June 2023 were selected,bile was collected from all patients for bacterial culture and drug sensitivity test,the results of the test were statistically analyzed,and the main distribution of pathogenic bacteria and their resistance to antibiotics were analyzed.Result:Among 150 patients with cholelithiasis complicated with biliary tract infection,248 strains of pathogenic bacteria were cultured,including 175 strains(70.56%)of Gram-negative bacteria,mainly Escherichia coli,Klebsiella pneumoniae and Enterobacter cloacae;52 strains(20.97%)of Gram-positive bacteria,mainly Enterococcus faecalis and Enterococcus faecium;21 strains(8.47%)of fungi.The results of drug resistance showed that Escherichia coli was highly resistant to Ampicillin and Cefazolin(resistance rate>60%),but not resistant to Amikacin(sensitivity rate was 100.0%).Klebsiella pneumoniae had the highest resistance to Ampicillin(100.0%)and was not resistant to Amikacin.The resistance rate of Enterobacter cloacae to Ampicillin/Sulbactam,Ampicillin,Cefuroxime,Cefazolin and Cefoxitin were 100.0%.It was not resistant to Cefepime,Minocycline,Imipenem,Meropenem and Amikacin.Conclusion:The pathogenic bacteria of patients with cholelithiasis complicated with biliary tract infection are mostly Gram-negative bacteria,followed by Gram-positive bacteria,and different pathogenic bacteria have different resistance rates to antibiotics.Therefore,antibiotics should be rationally selected according to the results of drug sensitivity test,so as to reduce the burden of patients and drug-resistant strains while ensuring their clinical efficacy.
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