Effect of Modified Radical Mastectomy Combined with Neoadjuvant Chemotherapy on Patients with Triple-negative Breast Cancer
Objective:To investigate the effect of modified radical mastectomy combined with neoadjuvant chemotherapy on patients with triple-negative breast cancer.Method:A total of 90 patients with triple-negative breast cancer admitted to the Department of Breast and Thyroid Surgery of Putian First Hospital from January 2018 to December 2020 were selected.According to the random numerical table method,they were divided into control group and observation group,45 cases in each group.The control group was given modified radical mastectomy,and the observation group was given modified radical mastectomy combined with neoadjuvant chemotherapy.Perioperative indexes,postoperative complications,health and physical status,and 3-year follow-up condition were compared between the two groups.Result:The operation time and postoperative hospital stay in the observation group were shorter than those in the control group,and the amount of intraoperative blood loss was less than that in the control group,the differences were statistically significant(P<0.05).The incidence of postoperative complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the Karnofsky functional status rating scale(KPS)score of the observation group was higher than that of the control group,and the physical status rating scale score of the Eastern American Cancer Society Group(ZPS)was lower than that of the control group,the differences were statistically significant(P<0.05).The local recurrence rate and distant metastasis rate of observation group were lower than control group,and the 3-year survival rate was higher than control group,the differences were statistically significant(P<0.05).Conclusion:Triple negative breast cancer receiving modified radical mastectomy combined with neoadjuvant chemotherapy can obtain ideal long-term efficacy,improve the quality of life of patients and reduce the probability of disease recurrence.
Modified radical mastectomyNeoadjuvant chemotherapyTriple negative breast cancer
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