Effects of Intermittent High-flux Hemodialysis Combined with Levocarnitine Intravenous Injection in Maintenance Hemodialysis Patients
Objective:To explore the effect of intermittent high-flux hemodialysis(HFHD)combined with Levocarnitine intravenous dialysis in maintenance hemodialysis patients.Method:A total of 80 patients with maintenance hemodialysis who received treatment in Zhangzhou Second Hospital from March 2021 to May 2023 were selected and they were divided into the control group receiving intermittent HFHD(n=40)and the experimental group receiving intermittent HFHD combined with Levocarnitine intravenous injection(n=40)according to the random number table method.Iron metabolism level,microinflammatory status,quality of life and incidence of adverse reactions were compared between the two groups.Result:After 3 months of treatment,the transferrin saturation and ferritin level in the two groups were higher than before treatment,and the indexes in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of interleukin-6 and C-reactive protein in the two groups were lower than those before treatment,and the indexes in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the scores of quality of life measurement scale such as environmental,psychological,physiological,social relations in the two groups were higher than those before treatment,and the indexes in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).During treatment,the total incidence of adverse reactions in the two group were compared,but the difference was not statistically significant(P>0.05).Conclusion:Intravenous injection of intermittent HFHD combined with Levocarnitine can regulate the iron metabolism level in maintenance hemodialysis patients,improve the microinflammatory state,and contribute to the improvement of quality of life,with certain safety.
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