Clinical Observation of Ertong Qingyan Jiere Koufuye Combined with Clarithromycin in Treatment of Acute Upper Respiratory Tract Infection
Objective:To evaluate the clinical effect of Ertong Qingyan Jiere Koufuye combined with clarithromycin in the treatment of upper respiratory tract infection.Method:A total of 120 children with acute upper respiratory tract infection admitted to Jinshazhou Hospital of Guangzhou University of Traditional Chinese Medicine from December 2022 to June 2023 were selected as the study subjects and were randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with clarithromycin dispersive tablets,and the observation group was treated with Ertong Qingyan Jiere Koufuye on the basis of the control group.After 5 days of treatment,the changes of clinical symptom score,complete fever regression time,blood image recovery time,blood image/inflammatory factor changes,ibuprofen use and safety in the two groups were observed.Result:After 5 days of treatment,the symptom scores of both groups were decreased,and the decrease was more obvious in the observation group,with statistical significance(P<0.05).The time of complete fever regression and the time of routine blood routine normalization in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).After 5 days of treatment,white blood cell count(WBC),neutrophil(NEUT),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were decreased in both groups,and the decrease was more significant in the observation group,the difference was statistically significant(P<0.05).The use of ibuprofen was significantly lower in the observation group than that in the control group.During observation and treatment,no adverse events related to drug use were found in the two groups,and the safety was good.Conclusion:The combination of clarithromycin and Ertong Qingyan Jiere Koufuye in the treatment of acute upper respiratory tract infection can significantly improve symptoms,shorten the course of the disease,improve the abnormal blood image and inflammatory factor expression.
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