地塞米松玻璃体内植入剂对视网膜静脉阻塞伴黄斑水肿患者视力水平的改善效果
Effect of Dexamethasone Intravitreal Implant on Visual Acuity in Patients with Retinal Vein Occlusion and Macular Edema
陈泽霖 1李秀兰1
作者信息
- 1. 泉州市第一医院 福建 泉州 362000
- 折叠
摘要
目的:研究地塞米松玻璃体内植入剂对视网膜静脉阻塞(RVO)伴黄斑水肿患者视力水平的改善效果.方法:选取 2020 年 1 月—2022 年 12 月泉州市第一医院眼科收治的 106 例RVO伴黄斑水肿患者作为研究对象,以随机数字表法分组为对照组和试验组,每组各 53 例.对照组行雷珠单抗单独治疗,试验组行地塞米松玻璃体内植入剂单独治疗.监测两组治疗前后视力水平与黄斑中心凹厚度变化,统计不良反应发生率并对患者生存质量进行评价.结果:试验组治疗后 3 个月、6个月的视力水平较对照组好,差异有统计学意义(P<0.05);试验组治疗后 6 个月的黄斑中心凹厚度较对照组低,差异有统计学意义(P<0.05);试验组治疗后 6 个月的视觉相关生存质量得分较对照组高,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:地塞米松玻璃体内植入剂治疗RVO伴黄斑水肿患者时能更好地改善长期视力水平和黄斑水肿症状,患者生存质量更好.
Abstract
Objective:To study the improvement effect of dexamethasone intravitreal implantation on visual acuity in patients with retinal vein occlusion(RVO)and macular edema.Method:A total of 106 patients with RVO with macular edema admitted to the Ophthalmology Department of Quanzhou First Hospital from January 2020 to December 2022 were selected as the subjects.They were divided into control group and test group by random number table method,with 53 cases in each group.And then the cases of control group were treated with lezumab alone,while the cases of text group were treated with dexamethasone intravitreal implant alone.The visual acuity level and the thickness of macular fovea were monitored before and after treatment,the incidence of adverse reactions was calculated,and the quality of life of patients was evaluated.Result:The visual acuity level of the experimental group was better than that of the control group 3 and 6 months after treatment,and the difference was statistically significant(P<0.05).The macular fovea thickness in the experimental group was lower than that in the control group 6 months after treatment,and the difference was statistically significant(P<0.05).The visual related quality of life score of the experimental group was higher than that of the control group 6 months after treatment,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two group(P<0.05).Conclusion:Dexamethasone intravitreal implant in the treatment of RVO patients with macular edema can better improve the long-term vision level and symptoms of macular edema,and the quality of life of patients is better.
关键词
视网膜静脉阻塞/黄斑水肿/雷珠单抗/地塞米松玻璃体内植入剂/视力水平/生存质量Key words
Retinal vein occlusion/Macular edema/Leizumab/Dexamethasone intravitreal implant/Visual acuity level/Quality of Life引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据