Clinical Study of Probiotics on Intestinal Microecology in Patients with Hyperlipidemia
Objective:A total of 80 patients with hyperlipidemia admitted to Nanping First Hospital Affiliated to Fujian Medical University from July 2021 to July 2023 were selected for the experiment.They were divided into probiotics group(n=40)and rosuvastatin group(n=40)by computer system randomization.The rosuvastatin group was treated with rosuvastatin,and the probiotic group was treated with probiotics on the basis of the rosuvastatin group.The levels of blood lipids,changes of intestinal microecology and incidence of cardiovascular diseases were compared between the two groups before and after treatment.In addition,Pearson correlation analysis was used to determine the relationship between the level of lipid indexes and the content of intestinal flora in patients with hyperlipidemia.Result:After treatment,the levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),apolipoprotein B and lipoprotein a in both groups were lower than before treatment,and the probiotic preparation group was lower than rosuvastatin group,with statistical significance(P<0.05).After treatment the high density lipoprotein cholesterol(HDL-C)level was higher than before treatment,and the probiotic preparation group was higher than rosuvastatin group,with statistical significance(P<0.05).After treatment,the contents of Intestinal bifidobacterium,Lactobacillus,Escherichia coli and Enterococcus faecalis in 2 groups were higher than before treatment,and the probiotic preparation group was higher than rosuvastatin group,with statistical significance(P<0.05).There was no significant difference in the comparison of cardiovascular diseases between the two groups(P>0.05).According to Pearson correlation analysis,the contents of intestinal bifidobacterium,lactobacillus,Escherichia coli and Enterococcus faecalis in hyperlipidemia patients were positively correlated with the levels of TG,TC,LDL-C,apolipoprotein B and lipoprotein a,while negatively correlated with the levels of HDL-C,with statistical significance(P<0.05).Conclusion:The application of probiotics can effectively improve the level of blood lipids and intestinal microecology in patients with hyperlipidemia.
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