Effect of Prolonged Antibiotic Infusion Time or Increased Dose on Efficacy and Safety of Patients Infected with Pseudomonas Aeruginosa RICU
Objective:To investigate the effect of prolonged antibiotic infusion time or increased dose on the efficacy and safety of patients with pseudomonas aeruginosa(PA)infection in respiratory intensive care unit(RICU).Method:150 patients were divided into groups A,B and C by random number table method,with 50 cases in each group.Group A received high-dose 30 min infusion therapy,group B received high-dose 3 h infusion therapy,and group C received low-dose 3 h infusion therapy.The changes of body temperature and white blood cell count,total effective rate,bacterial clearance rate and the incidence of adverse reactions during treatment were compared among the 3 groups.Result:After treatment,the body temperature and white blood cell count of 3 groups were decreased,the difference was statistically significant(P<0.05).After treatment,the body temperature and white blood cell count of group B were lower than those of group A and group C,the difference was statistically significant(P<0.05).After treatment,there was no significant difference in body temperature and white blood cell count between groups A and C(P>0.05).The total effective rate of the three groups was statistically significant(P<0.05).The total effective rate of group B was higher than that of group C,the difference was statistically significant(P<0.05).The total effective rate of group B was higher than that of group A,with no statistical significance(P>0.05).There was no significant difference between group A and group C(P>0.05).There was statistical significance in the bacterial clearance rate of 3 groups on the day of drug withdrawal(P<0.05).The bacterial clearance rate of group B was higher than that of group A and group C,the difference was statistically significant(P<0.05).There was no significant difference in bacterial clearance between groups A and C(P>0.05).The adverse reaction rates of the three groups were 5.3%,5.3%and 4.0%,respectively,with no statistical significance(P>0.05).There was statistical significance in the length of hospital stay among the three groups(P<0.05).The hospitalization time of RICU in group B was lower than that in group A and group C,and the difference was statistically significant(P<0.05).There was no significant difference between group A and group C(P>0.05).Conclusion:Appropriately prolonging the infusion time and increasing the dosage of meropenem can improve the therapeutic effect of patients with Pseudomonas aeruginosa infection in RICU with good.
Infusion timeMeropenemPseudomonas aeruginosaDoseRspiratory intensive care unitTherapeutic effect
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