Effect of Compound Danshen Dropping Pills on Chronic Mountain Sickness Patients
Objective:To investigate the effect of Compound Danshen Dropping Pills on patients with chronic mountain sickness(CMS).Method:A total of 86 patients with CMS admitted to the Fifth People's Hospital of Qinghai Province from February 2022 to February 2023 were retrospectively selected.According to different method of treatment,the patients were divided into study group and control group,43 cases in each group.Both groups were given conventional treatment,the control group was treated with Phentolamine Mesylate Injection,and the study group was given Compound Danshen Dropping Pills on the basis of the control group.The relevant indexes,left ventricular structure,left ventricular function,lung function,6 min walking distance before and after treatment and clinical efficacy of the two groups were compared.Result:After treatment,norepinephrine(NE),epinephrine(E),atrial natriuretic peptide(ANP)and endothelin(ET)were decreased in both groups,while nitric oxide(NO)was increased,NE,E,ANP and ET in the study group were lower than those in the control group,and NO was higher than that in the control group,the differences were statistically significant(P＜0.05).After treatment,left ventricular end-diastolic diameter(LVEDD),left ventricular posterior wall thickness(PWT)and ventricular septal thickness(IVS)were decreased in both groups,and LVEDD,IVS and PWT in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).After treatment,atrial systolic mitral valve velocity(A)decreased,while mitral valve velocity during left ventricular rapid filling phase(E),E/A,left ventricular ejection fraction(LVEF)and cardiac output(CO)increased in both groups,and A in study group was lower than that in control group,and E,E/A,LVEF and CO were higher than those in control group,the differences were statistically significant(P＜0.05).After treatment,pulmonary artery pressure(PAP)decreased,forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC%,6 minutes walking test(6MWT)increased in both groups,PAP in the study group was lower than that in the control group,and FVC,FEV1,FEV1/FVC%,6MWT distance were higher than those in the control group,the differences were statistically significant(P＜0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion:The Compound Danshen Dropping Pills has obvious improvement on the cardiopulmonary function structure of CMS patients,and the clinical effect is good.
Ultrasonic cardiogramCompound Danshen Dropping PillsChronic mountain sicknessCardiopulmonary function
万方数据
维普
