Effects of BAL and NPPV in the Treatment of COPD Patients with Atelectasis
Objective:To investigates the effects of bronchoalveolar lavage(BAL)and non invasive positive pressure ventilation(NPPV)in the treatment of chronic obstructive pulmonary disease(COPD)patients with atelectasis.Method:A total of 84 patients with COPD and atelectasis admitted to the Respiratory Department of Xishui County Traditional Chinese Medicine Hospital from February 2020 to February 2023 were selected.According to random number table method,the patients were divided into treatment group and control group,42 cases in each group.Both groups were given conventional drug treatment,BAL treatment in the treatment group and NPPV treatment in the control group.Dyspnea,pulmonary function indexes,arterial blood gas indexes and related indexes before and after treatment were compared between the two groups.Result:After treatment,the modified Medical Research Council(mMRC)score of the two groups decreased,and the mMRC score of the treatment group was lower than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and FEV1 in the predicted value(FEV1%pred)of the two groups were increased,and the FVC,FEV1 and FEV1%pred of the treatment group were higher than those of the control group,the differences were statistically significant(P＜0.05).After treatment,arterial oxygen saturation(SaO2)and arterial partial pressure of oxygen(PaO2)were significantly increased in both groups,while arterial partial pressure of carbon dioxide(PaCO2)was decreased,SaO2 and PaO2 in the treatment group were higher than those in the control group,and PaCO2 was lower than that in the control group,the differences were statistically significant(P＜0.05).After treatment,the levels of soluble trigger receptor expression gene 1(sTREM-1)and high mobility group protein B1(HMGB1)were significantly decreased in both groups,and the levels of sTREM-1 and HMGB1 in the treatment group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion:BAL and NPPV treatment can effectively improve the symptoms and lung function of COPD patients with atelectasis,and BAL treatment is better than NPPV treatment.Both treatments can reduce sTREM-1 and HMGB1 levels in COPD patients with atelectasis,suggesting that both treatments can reduce inflammatory response,and BAL treatment has better anti-inflammatory effect than NPPV treatment.
Bronchoscopic alveolar lavageNon invasive positive pressure ventilationChronic obstructive pulmonary diseaseAtelectasisSoluble trigger receptor gene 1High mobility group protein B1
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维普
