Comparative the Effects of Olanzapine and Risperidone in the Treatment of Schizophrenia and the Effects on Myocardial Enzymes
Objective:To compare the effects of Olanzapine and Risperidone in the treatment of schizophrenia and the effects on myocardial enzymes.Method:From October 2021 to October 2022,80 cases of patients with schizophrenia were selected from Huai'an Xin'an Hospital,they were divided into two groups according to different medication regiments.40 cases who were treated with Olanzapine as group A and 40 cases who were treated with Risperidone as group B.The symptom improvement,total effective rate,drug side effects and myocardial enzymes were compared between the two groups.Result:There was no significant difference in positive and negative syndrome scale(PANSS)scores between group A and group B after treatment,the difference was not statistically significant(P＞0.05).The total effective rate of group A and group B was 92.50%and 95.00%,respectively,the difference was not statistically significant(P＞0.05).The scores of the cardiovascular system of treatment emergent symptom scale(TESS)in group A were higher than those in group B,the difference was statistically significant(P＜0.05),and the scores of other items in TESS between the two groups were compared,the difference was not statistically significant(P＞0.05).Creatine kinase isoenzyme(CK)and creatine kinase isoenzyme(CKMB)in group A were higher than those in group B after treatment,the difference was statistically significant(P＜0.05).Conclusion:In the treatment of schizophrenia,both Olanzapine and Risperidone can effectively improve related symptoms,with similar efficacy,but Olanzapine has a more obvious effect on myocardium,which can lead to the increase of myocardial enzyme levels.Clinically,the two drugs should be rationally selected according to the actual situation of patients.
万方数据
维普
