Efficacy of Esesomeprazole Combined with Octreotide Acetate in the Treatment of Acute Upper Gastrointestinal Bleeding
Objective:To investigate the efficacy of Esesomeprazole combined with Octreotide Acetate in the treatment of acute upper gastrointestinal bleeding.Method:A total of 400 patients with acute upper gastrointestinal bleeding admitted to Qianxi People's Hospital from January to December 2023 were selected.According to random number table method,they were divided into observation group and control group,200 cases in each group.The control group was treated with Esomeprazole Sodium for Injection,and the observation group was treated with Octreotide Acetate Injection based on the control group.The clinical efficacy,blood routine,blood urea nitrogen(BUN),coagulation function before and after treatment and adverse reactions of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,hemoglobin(Hb)and red blood cell count(RBC)in both groups were increased,and Hb and RBC in observation group were higher than those in control group,the differences were statistically significant(P＜0.05).After treatment,BUN decreased in both groups,and BUN in observation group was lower than that in control group,the difference was statistically significant(P＜0.05).After treatment,the prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D)were decreased,platelet count(PLT),erythroid cell specific volume(HCT),fibrinogen(FIB)were increased in two groups,PT,APTT,D-D in the observation group were lower than those in the control group,and the PLT,HCT,and FIB were higher than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The combination of Esesomeprazole and Octreotide Acetate is beneficial to improving the clinical efficacy of patients with acute upper gastrointestinal bleeding,improving blood routine indexes,blood biochemical indexes and coagulation function,and has good safety.
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维普
