Objective:To analyze the effect of low dose Budesonide combined with Terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 100 patients with AECOPD admitted to the Second Affiliated Hospital of Xuzhou Medical University from January to December 2022 were selected.According to the random method,they were divided into single drug group and two-drug group,with 50 cases in each group.The single drug group was given Terbutaline treatment,and the two drug group were given low doses Budesonide based on the single drug group.The clinical efficacy,severity of symptoms,lung function,immune function before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the two drug group was higher than that of the single drug group,and the difference was statistically significant(P＜0.05).After treatment,the self assessment form for chronic obstructive disease patients(CAT)scores of both groups were decreased,and the forced expiratory volume in the first second(FEV1),the maximum volume of gas(MVV),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were increased,and the CAT scores of the two drug group were lower than those of the single drug group,FEV1,MVV,IgA,IgG and IgM were higher than those in single drug group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The combination of Budesonide+Terbutaline in AECOPD patients can quickly eliminate disease symptoms,promote lung function recovery,and regulate immunity without increasing adverse reactions,and has a good safety.
关键词
慢性阻塞性肺疾病急性加重期/布地奈德/特布他林
Key words
Acute exacerbation of chronic obstructive pulmonary disease/Budesonide/Terbutaline
维普
万方数据