Objective:To analyze application effect of Bedaquiline in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB).Method:A total of 60 MDR-TB patients admitted to Maoming Chronic Disease Prevention and Control Center from January 2022 to June 2023 were selected.They were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was treated with individualized antituberculosis drugs,and the observation group was treated with Bedaquiline on the basis of the control group.The clinical efficacy,related indexes,quality of life before and after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05).The negative conversion rate of sputum and the effective rate of lesion absorption in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the scores of physiological function,vitality,body pain and general health status of the observation group were higher than those of the control group,and the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The addition of Bedaquiline therapy for MDR-TB patients can better improve the disease symptoms,increase the sputum negative conversion rate,and improve the quality of life of patients.
关键词
耐多药肺结核/痰菌转阴率/生活质量/应用效果
Key words
Multidrug-resistant pulmonary tuberculosis/Sputum negative conversion rate/Quality of life/Application effect
维普
万方数据