Effect on Clinical Efficacy of Irbesartan in Patients with Coronary Heart Disease after PCI
Objective:To observe the clinical effect of Irbesartan on patients with coronary heart disease after percutaneous coronary intervention (PCI).Method:A total of 120 patients with coronary heart disease after PCI treated in Affiliated Hospital of Jiangnan University from January 2021 to December 2023 were selected and they were randomly divided into group A (n=60) and group B (n=60).Group A received conventional treatment,group B received conventional treatment+Irbesartan treatment.The occurrence of angina pectoris (attack frequency,duration),blood lipid levels[triglycerides (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C)],cardiac function indicators[left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic diameter (LVESD),left ventricular ejection fraction (LVEF)],oxidative stress level[superoxide dismutase (SOD),malondialdehyde (MDA)],and clinical efficacy were compared between the two groups.Result:After treatment,the frequency and duration of angina pectoris were decreased in the two groups,and which in group B were less than those in group A,the differences were statistically significant (P<0.05).TG,TC,HDL-C and LDL-C were all improved in the two groups after treatment,and the levels in group B were better than those in group A,the differences were statistically significant (P<0.05).LVEDD,LVESD and LVEF were all improved in the two groups after treatment,and the levels in group B were better than those in group A,the differences were statistically significant (P<0.05).SOD and MDA of the two groups were improved after treatment,and the levels in group B were better than those in group A,the differences were statistically significant (P<0.05).The total effective rate of group B was higher than that of group A,the difference was statistically significant (P<0.05).Conclusion:The application of Irbesartan in patients with coronary heart disease after PCI has a good effect,which can reduce the frequency and duration of angina pectoris,improve blood lipid level,cardiac function index and oxidative stress level,and the total effective rate is high.
万方数据
维普
