Objective:To investigate the effect of Human Growth Hormone Injection combined with Vitamin D3 in the treatment of children with nanosomia.Method:A total of 80 children with nanosomia treated in Putian Children's Hospital from January 2022 to January 2023 were selected.They were randomly divided into observation group and control group,40 cases in each group.The control group was given Human Growth Hormone Injection,and the observation group was given Vitamin D3 based on the control group.Growth and development indexes,serum growth factor and 25-hydroxyvitamin D[25(OH)D]levels,bone metabolism indexes before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,the height and weight of both groups increased,and the height,weight and growth rate of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).After treatment,the levels of insulin-like growth factor binding protein-3 (IGFBP-3),25(OH)D,and insulin-like growth factor-1 (IGF-1) increased in both groups,the levels of IGFBP-3,25(OH)D,and IGF-1 in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the levels of osteocalcin (OC),bone alkaline phosphatase (BAP) and amino terminal propeptide of type Ⅰ procollagen (PINP) were increased in both groups,and the levels of OC,BAP and PⅠNP in observation group were higher than those in control group,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Treatment with Human Growth Hormone Injection combined with Vitamin D3 can regulate the levels of serum growth factor and 25(OH)D,improve bone metabolism indexes,promote growth and development without increasing adverse reactions,and has a good safety.
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