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广泛期小细胞肺癌一线治疗现状及研究进展

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小细胞肺癌(small cell lung cancer,SCLC)恶性程度极高,易早期发生复发转移,预后差。以化疗为主要治疗方式的广泛期SCLC(extensive stage SCLC,ES-SCLC)中位生存期仅8~12个月。免疫治疗联合化疗的综合治疗模式使ES-SCLC患者的生存期较之前有了一定的提高,但两项大规模的临床研究CASPIAN和IMpower133都仅仅提高了不到3个月的生存期。本文将对ES-SCLC的一线治疗现状及研究进展进行综述。
Current Status and Research Progress of First-line Treatment of Extensive Small Cell Lung Cancer
Small cell lung cancer (SCLC) is highly malignant,prone to early recurrence and metastasis,and has a poor prognosis.The median survival for extensive stage SCLC (ES-SCLC) with chemotherapy as the main treatment method is only 8 to 12 months.The combined treatment mode of immunotherapy combined with chemotherapy improved the survival of patients with ES-SCLC to a certain extent than before,but two large-scale clinical studies CASPIAN and IMpower133 only improved the survival of less than 3 months.This article will review the current status and research progress of first-line treatment of ES-SCLC.

Malignant tumorSmall cell lung cancerExtensive stageChemotherapyImmunotherapy

王立东

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迁安市人民医院 河北 迁安 064400

恶性肿瘤 小细胞肺癌 广泛期 化疗 免疫治疗

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(29)