Application of Subanesthetic Dose Esketamine in Patients Undergoing Pulmonary Surgery during Anesthesia Induction Stage
Objective:To analyze the application effect of subanesthetic dose Esketamine in patients undergoing pulmonary surgery during anesthesia induction stage.Method:A total of 106 pulmonary surgery patients admitted to Xinchang County People's Hospital from January 2022 to March 2024 were selected as the research subjects,and randomly divided into control group and study group,with 53 cases in each group.The control group was anesthetized with Midazolam+Sufentanil+Cisatracurium+Etomidate,while the study group was anesthetized with subanesthetic dose Esketamine(0.3 mg/kg)on the basis of the control group.The mean arterial pressure(MAP),heart rate(HR)and bifrequency index(BIS)of the two groups were compared before anesthesia induction(T0),immediately after successful two-lumen bronchial intubation(T1),immediately after extubation(T2),10 min after extubation(T3)and 30 min after extubation(T4).Visual analogue scale(VAS)scores were compared between the two groups at 6 h,12 h,24 h and 48 h after surgery,and the incidence of adverse reactions was analyzed.Result:T0,there was no significant difference in MAP,HR and BIS between the two groups(P>0.05).Compared with T0,T1,T2,T3,T4 MAP and HR in two groups were increased,but those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The T1 BIS of two groups were higher than those at T0,and the T1 BIS of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in T2,T3 and T4 BIS between the two groups(P>0.05).At 6 h,12 h and 24 h after surgery,VAS scores in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 11.3%,lower than 28.3%in the control group,and the difference was statistically significant(P<0.05).Conclusion:The combined application of subanesthetic dose Esketamine in the anesthesia induction stage is beneficial to reduce the intraoperative hemodynamic fluctuation and postoperative pain of patients with lung surgery,and has certain safety and is conducive to the prognosis of patients.
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