Objective:To explore the application effect of airway pressure release ventilation(APRV)mode combined with prone ventilation in patients with moderate to severe acute respiratory distress syndrome(ARDS).Method:According to the random number table method,91 patients with moderate to severe ARDS admitted to Xuzhou Cancer Hospital and Xuzhou New Healthy Hospital from June 2022 to May 2023 were divided into the control group(n=45,prone ventilation)and the observation group(n=46,combined with APRV mode on the basis of the control group).The arterial blood gas index,respiratory function and clinical prognosis of the two groups were assessed and compared.Result:The levels of arterial oxygen saturation(SaO2),pulmonary dynamic compliance(Cydn),arterial partial pressure of oxygen(PaO2)and oxygenation index(PaO2/FiO2)in the observation group were higher than in the control group at 1 h,24 h and 48 h of treatment,and the levels of mean airway pressure(Pmean),arterial partial pressure of carbon dioxide(PaCO2),peak airway pressure(Ppeak)in the observation group were lower than in the control group,duration of mechanical ventilation and intensive(ICU)were shorter than those of the control group,and the differences were statistically significant(P<0.05).The 28 d morbidity and mortality rate of the observation group was lower than that of the control group(10.87%vs.28.89%),and the difference was statistically significant(P<0.05).Conclusion:APRV mode combined with prone ventilation can significantly improve arterial blood gas indexes,respiratory function,oxygenation function and lung compliance in patients with moderate to severe ARDS,shorten ventilation time and hospital stay,and promote good prognosis.
维普
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