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布地奈德雾化吸入联合丙种球蛋白对新生儿肺炎的影响

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目的:探究布地奈德雾化吸入联合丙种球蛋白对新生儿肺炎的影响。方法:选取 2018 年 1 月—2023 年 1 月连云港市第二人民医院新生儿科收治的 100 例新生儿肺炎患儿作为研究对象。根据随机数表法将其分为对照组和观察组,各50 例。两组均给予基础治疗,对照组给予常规西药治疗,观察组在对照组的基础上给予布地奈德雾化吸入联合丙种球蛋白治疗。比较两组症状消失时间及住院时间,治疗前后炎症因子。结果:观察组咳嗽、咳痰、喘息消失时间均早于对照组,住院时间短于对照组,差异有统计学意义(P<0。05)。治疗后,观察组降钙素原、C反应蛋白、白细胞计数、中性粒细胞与淋巴细胞比值(NLR)水平均低于对照组,差异有统计学意义(P<0。05)。结论:对新生儿肺炎患儿采取布地奈德雾化吸入联合丙种球蛋白干预,能够降低患儿的血清炎性指标,帮助患儿尽早恢复,提高临床疗效。
Effect of Budesonide Nebulized Inhalation Combined with Gamma Globulin on Neonatal Pneumonia
Objective:To investigate the effect of Budesonide nebulized inhalation combined with gamma globulin on neonatal pneumonia.Method:A total of 100 children with neonatal pneumonia admitted to the Department of Neonatology of the Lianyungang Second People's Hospital from January 2018 to January 2023 were selected as the study subjects.According to the random number table method,they were divided into control group and observation group,with 50 cases in each group.Both groups were given basic treatment,the control group was treated with conventional western medicine,and the observation group was treated with Budesonide nebulized inhalation combined with gamma globulin on the basis of the control group.The disappearance time and length of hospital stay,and the inflammatory factors before and after treatment were compared between the two groups.Result:The disappearance time of cough,sputum production and wheezing in the observation group was earlier than that in the control group,and the hospital stay was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of procalcitonin,C-reactive protein,white blood cell count and neutrophil-to-lymphocyte ratio(NLR)in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Budesonide nebulization inhalation and gamma globulin intervention can reduce serum inflammatory markers in neonatal pneumonia,help them recover early,and improve clinical efficacy.

BudesonideGamma globulinNeonatal pneumonia

沈建超、尹大猛

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连云港市第二人民医院 江苏 连云港 222002

布地奈德 丙种球蛋白 新生儿肺炎

2024

中外医学研究
中国医院管理杂志社

中外医学研究

影响因子:1.149
ISSN:1674-6805
年,卷(期):2024.22(34)