摘要
目的:探讨凝血六项[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、D-二聚体(D-D)、国际标准化比率(INR)]、血小板计数(PLT)及血栓四项[凝血酶-抗凝血酶复合物(TAT)、纤溶酶-α2 纤溶酶抑制物复合物(PIC)、组织纤溶酶原激活物/纤溶酶原激活物抑制剂-1 复合物(tPAI-C)、血栓调节蛋白(TM)]在恶性肿瘤预后评估中的应用.方法:回顾性分析 2023 年 3 月—2024 年 2 月连云港市第二人民医院收治的 118例恶性肿瘤患者.收集所有患者的一般资料.比较两组一般资料.分析凝血六项、PLT、血栓四项与恶性肿瘤患者预后的相关性.分析凝血六项、PLT、血栓四项对恶性肿瘤患者预后的预测价值.结果:好反应组PT、APTT、tPAI-C、TM均高于差反应组,TT、INR、PLT、FIB、D-D、TAT、PIC均低于差反应组,差异有统计学意义(P<0.05).与预后的相关性由高到低为TM、PIC、INR、D-D、PT、TAT、TT、FIB、APTT、tPAI-C、PLT.PT、APTT、tPAI-C、TM与预后呈正相关,PLT、PIC、D-D、TT、TAT、FIB、INR与预后呈负相关(P<0.05).联合检测敏感度为 96.154%,特异度为 89.130%,AUC为 0.960.结论:凝血六项、血小板计数、血栓四项指标的异常与肿瘤的进展密切相关,可作为恶性肿瘤预后评估中的重要手段.
Abstract
Objective:To investigates the clinical significance of six coagulation parameters[plasma prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),D-Dimer(D-D),and international normalized ratio(INR)],platelet count(PLT),and the thrombosis four parameters[plasma thrombin-antithrombin complex(TAT),plasmin-α2 antiplasmin complex(PIC),plasminogen activator inhibitor-1 complex(tPAI-C),and thrombomodulin(TM)]in the prognostic assessment of patients with malignant tumors.Method:A retrospective analysis was performed on 118 patients with malignant tumors admitted to the Lianyungang Second People's Hospital from March 2023 to February 2024.General data of all patients were collected.General data were compared between the two groups.The correlation of six items of coagulation,PLT and thrombus four parameters with prognosis of patients with malignant tumor was analyzed.The prognostic value of six items of coagulation,PLT and thrombus four parameters in malignant tumor patients were analyzed.Result:The PT,APTT,tPAI-C and TM in the good response group were higher than those in the poor response group,while the TT,INR and PLT,FIB,D-D,TAT,PIC in the good response group were lower than those in the poor response group,the differences were statistically significant(P<0.05).The correlations with prognosis were TM,PIC,INR,D-D,PT,TAT,TT,FIB,APTT,tPAI-C and PLT from high to low.PT,APTT,tPAI-C,TM were positively correlated with prognosis,PLT,PIC,D-D,TT,TAT,FIB,INR were negatively correlated with prognosis(P<0.05).The sensitivity,specificity and AUC of combined detection were 96.154%,89.130%and 0.960 respectively.Conclusion:The abnormalities of six indexes of coagulation,platelet count and thrombus four parameters are closely related to the progression of tumor,and can be used as an important means to evaluate the prognosis of malignant tumor.
维普
万方数据