Effect of Bronchofiberscope Sputum Aspiration and Lavage Combined with Xuebijing in the Treatment of Patients with Severe Pneumonia Complicated with Respiratory Failure
Objective:To investigate the effect of bronchofiberscope sputum aspiration and lavage combined with Xuebijing in the treatment of patients with severe pneumonia(SP)complicated with respiratory failure(RF).Method:A total of 65 patients with SP complicated with RF who treated in Baoying Eryuan Hospital from January 2021 to December 2023 were selected as the research objects,the patients were divided into the cooperation group(n=32)and the control group(n=33)by computer random arrangement method.The control group was treated with bronchofiberscope sputum aspiration and lavage,and the cooperation group was treated with additional Xuebijing on the basis of the control group.The therapeutic effect,rehabilitation indexes,pulmonary function indexes,serum differentiated cluster 40 ligand(CD40L)and decoy receptor 3(DcR3)levels were compared between two groups.Result:The total effective rate of the cooperation group was higher than that of the control group,and the disappearance time of cough and pulmonary rales,mechanical ventilation time and intensive care unit(ICU)treatment time were shorter than those of the control group,the differences were statistically significant(P<0.05);after 2 weeks of treatment,the forced expiratory volume for one second(FEV1),FEV1/forced vital capacity(FVC)and peak expiratory flow(PEF)in two groups were higher than those before treatment,and those in the cooperation group were higher than those in the control group,the differences were statistically significant(P<0.05);after 2 weeks of treatment,the levels of serum CD40 L and DcR3 in two groups were lower than those before treatment,and those in the cooperation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Bronchofiberscope sputum aspiration and lavage combined with Xuebijing in the treatment of patients with SP complicated with RF is effective,and which can promote the rehabilitation of lung function and reduce the levels of serum CD40 L and DcR3.
Severe pneumoniaRespiratory failureBronchofiberscope sputum aspiration and lavageXuebijingDifferentiation cluster 40 ligandDecoy receptor 3
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