Levels and Clinical Significance of Serum IL-10,IL-17,IL-35 and INF-γ in Patients with Autoimmune Thyroiditis
Objective:To analyze the levels and clinical significance of serum interleukin-10(IL-10),interleukin-17(IL-17),interleukin-35(IL-35)and interferon-γ(INF-γ)in patients with autoimmune thyroiditis(AIT).Method:A total of 78 patients with AIT admitted to Hui'an County Hospital from January 2021 to February 2023 as the AIT group,and 40 healthy individuals who received health check-ups in the hospital were selected at the same time as the control group.Thyroid detection indicators[free thyroxine(FT4),free triiodothyronine(FT3),thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)]and serum levels of IL-10,IL-17,IL-35 and INF-γ were compared between the two groups.Pearson method was used to analyze the correlation between thyroid detection indicators and IL-10,IL-17,IL-35 and INF-γ.logistic regression model was used to analyze the influencing factors of AIT.Result:There were no statistically significant differences in FT4,FT3 between the two groups(P＞0.05).The levels of TGAb and TPOAb in AIT group were higher than those in control group,the differences were statistically significant(P＜0.05).Serum IL-17 and INF-γ levels in AIT group were higher than those in control group,the levels of IL-10 and IL-35 were lower than those in control group,the differences were statistically significant(P＜0.05).IL-10 and IL-35 were negatively correlated with TGAb and TPOAb,IL-17 and INF-γ were positively correlated with TGAb and TPOAb(P＜0.05).IL-10 and IL-35 were protective factors for AIT,IL-17 and INF-γ were risk factors for AIT(P＜0.05).Conclusion:There are abnormal decreases in serum IL-10 and IL-35 levels,and abnormally increases in the levels of IL-17 and INF-γ in patients with AIT.Above indicators are closely related to the condition of AIT.IL-10 and IL-35 are protective factors for AIT,while IL-17 and INF-γ are risk factors.
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