Effect of Argatroban on Patients with Progressive Cerebral Infarction
Objective:To study the effect of Argatroban on patients with progressive cerebral infarction.Method:A total of 200 patients with progressive cerebral infarction admitted to Yixing People's Hospital from January 2021 to December 2023 were selected as the study objects.According to random number table method,they were divided into experimental group and control group,100 cases in each group.The control group was given Aspirin Enteric-coated Tablets,and the experimental group was given Argatroban Injection based on the control group.The clinical efficacy,adverse reactions,neurological function indexes,inflammatory response indexes and related indexes before and after treatment were compared between the two groups.Result:The total effective rate of experimental group was higher than that of control group,and the difference was statistically significant(P＜0.05).There were no obvious adverse reactions during treatment in both groups.After treatment,the National Institutes of Health stroke scale(NIHSS)score,neuropeptide Y(NPY)and neuron specific enolase(NSE)levels in both groups were decreased,and the NIHSS score,NPY and NSE levels in experimental group were lower than those in control group,the differences were statistically significant(P＜0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and soluble intercellular molecule 1(sICAM1)in both groups were decreased,and the levels of hs-CRP,IL-6 and sICAM1 in experimental groups were lower than those in control group,the differences were statistically significant(P＜0.05).After treatment,brain-derived neurotrophic factor(BDNF)levels were increased,amyloid A(SAA)and homocysteine(Hcy)levels were decreased in both groups,BDNF level in experimental group were higher than that in control group,and SAA and Hcy levels were lower than those in control group,the differences were statistically significant(P＜0.05).Conclusion:On the basis of Aspirin therapy,Argatroban in the treatment of progressive cerebral infarction can significantly improve the clinical effect,with good safety,but also effectively improve the neurological function and inflammatory status of patients,the mechanism may be related to the improvement of the level of neurotransmitters in patients.
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