慢性肾脏病并发肌少症的治疗研究进展
Research Progress on the Treatment of Chronic Kidney Disease Complicated with Sarcopenia
苗译亓1
作者信息
- 1. 南京中医药大学 江苏 南京 210023
- 折叠
摘要
慢性肾脏病(chronic kidney disease,CKD)作为一种慢性进展性疾病,可通过炎症反应、代谢性酸中毒、胰岛素抵抗、氧化应激、激素紊乱、蛋白质-能量营养不良等多种途径诱发肌少症,临床预后较差,已成为重大公共卫生问题,引起人们广泛关注.目前针对该部分患者,尚无完善的治疗策略,但多项研究表明运动、营养干预、激素疗法、AST-120、肌抑素(myostatin,MSTN)信号通路靶向治疗等措施或可改善患者营养状况,提高肌肉质量、力量,延缓疾病进展,本文就CKD并发肌少症的治疗研究进展予以综述.
Abstract
Chronic kidney disease(CKD)as a chronic progressive disease can induce sarcopenia through various pathways such as inflammation,metabolic acidosis,insulin resistance,oxidative stress,hormonal changes and protein-energy malnutrition,leading to poor clinical outcomes.It has become a major public health issue,drawing widespread attention.Currently,there is no comprehensive treatment strategy for these patients.However,multiple studies have shown that exercise,nutritional interventions,hormonal therapies,AST-120 and targeting treatment in the myostatin(MSTN)signaling pathway may improve the nutritional status of patients,increase muscle mass and strength,and delay disease progression.This article reviews the research progress in the treatment of CKD complicated with sarcopenia.
关键词
慢性肾脏病/肌少症/营养不良/治疗/肌抑素Key words
Chronic kidney disease/Sarcopenia/Malnutrition/Treatment/Myostatin引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据