The Effect of Vonoprazan Combined with Esomeprazole on the Level of Gastrointestinal Hormones and Therapeutic Efficacy in Patients with Hp-Positive Refractory Acid Reflux Disease
Objective:To investigate the clinical effect of combined administration of voronolazone and esomeprazole in patients with refractory gastroesophageal reflux(GERD)positive helicobacter pylori(Hp).Method:A total of 80 patients with Hp-positive refractory GERD treated in Dongtai People's Hospital from January 2021 to October 2023 were selected as the study objects,and grouped according to treatment differences,with 40 cases in each group.Patients in both groups received basic intervention.The control group was treated with esomeprazole,while the study group was treated with Vonolazine fumarate tables on the basis of control group.The levels of gastrointestinal hormones,inflammatory factors,adverse reactions and clinical efficacy of the two groups were compared.Result:Before treatment,there was no significant difference in gastrointestinal hormone levels between the two groups(P>0.05).After treatment,VIP in the study group was lower than that before treatment,and lower than that in control group,with statistically significance(P>0.05).After treatment,gastrin and motilin in study group were higher than that before treatment,with statistical significance(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors between the two groups(P>0.05).After treatment,CRP,C-creative protein,interleukin-6 and TNF-α in the study group were lower than those before treatment and lower than those in control group,and the difference was statistically significant(P<0.05).After treatment,the incidence of abdominal pain,diarrhea,nausea and vomiting in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Venolazan combined with esomeprazole can improve the level of gastrointestinal hormones and inflammatory factors in patients with Hp-positive refractory gastroesophageal reflux disease,thus improving the clinical effect of patients with high safety.
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