Effect of Platelet-rich Plasma Combined with Negative Pressure Sealing Drainage on Granulation Tissue Related Factors and Inflammatory Reaction in Patients with deep Second-Degree Burn
Objective:To analyze the effect of platelet-rich plasma combined with negative pressure sealing drainage on granulation tissue related factors and inflammatory reaction in patients with deep second-degree burn.Method:61 patients with deep second-degree burn admitted to the General Hospital of Ningxia Medical University from August 2019 to September 2023 were selected as the study objects and divided into the control group(30 cases)and the observation group(31 cases)by random number table method.The control group received negative pressure closed drainage treatment,while the observation group received platelet-rich plasma treatment on the basis of this,and both groups were treated until wound healing.The indexes of the two groups were compared.Result:The clinical total effective rate of the observation group was higher than that of the control group after 14 days of treatment(P<0.05).The levels of epidermal growth factor(EGF),basic fibroblast growth factor(bFGF),insulin-like growth factor(IGF)and platelet derived growth factor(PDGF)after 14 days of treatment were higher than those before treatment,and the observation group was higher than control group,and the difference was statistically significant(P<0.05).The levels of C-reaction protein(CRP),diamine oxidase(DAO)and white blood cell(WBC)in serum after 1 month of treatment were lower than those before treatment,and the the observation group was higher than control group(P<0.05).Conclusion:Platelet-rich plasma combined with negative pressure sealing drainage can up-regulate the expression of granulation tissue-related factors in patients with deep second-degree burn,promote wound healing and reduce its inflammatory reaction,with definite curative effect.
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