单人肠镜导入双歧杆菌治疗肠易激综合征患者临床疗效及对肠道菌群的作用分析
Clinical Efficacy of Introducing Bifidobacteria into a Single Colonoscope for the Treatment of Irritable Bowel Syndrome Patients and Analysis of Its Effect on Gut Microbiota
蔡明毅 1苏碧莲 1李夏薇1
作者信息
- 1. 晋江市医院(上海市第六人民医院福建医院) 福建晋江 362200
- 折叠
摘要
目的:研究分析肠易激综合征(IBS)患者采取单人肠镜导入双歧杆菌治疗的临床疗效及肠道菌群的作用.方法:选取 2021 年 2 月—2024 年 2 月晋江市医院收治的 98 例IBS患者作为研究对象,按照随机抽签法分为观察组和对照组,每组各 49 例.观察组采取单人肠镜导入双歧杆菌治疗,对照组采取匹维溴铵治疗.结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组双歧杆菌和乳酸杆菌数量以及乳脂球表皮生长因子-8(MFG-E8)水平高于对照组,大肠杆菌、粪肠球菌和D-乳酸(D-LA)水平低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生比较,差异无统计学意义(P>0.05).结论:在IBS的临床治疗中,采取单人肠镜导入双歧杆菌治疗有利于改善肠道菌群水平,为肠黏膜屏障功能恢复提供有效助力,有着较高的安全性.
Abstract
Objective:To investigate and analyze the clinical efficacy of single person colonoscopy with the introduction of bifidobacteria in patients with irritable bowel syndrome(IBS)and the role of gut microbiota.Method:98 IBS patients admitted to Jinjiang City Hospital from February 2021 to February 2024 were selected as the study objects and randomly divided into an observation group and a control group with 49 cases in each group.The observation group was treated with single person colonoscopy introducing bifidobacteria,while the control group treated with povidonium bromide.Result:The total effective rate of the observation group was higher than that of the control group(P<0.05).The number of Bifidobacterium and Lactobacillus,as well as the milk fat glotule-epidermal growth factor 8(MFG-E8)level in the observation group were higher than those in the control group,but the levels of Escherichia coli,Enterococcus faecalis,and D-lactic acid D-LA were lower than those in the control group(P<0.05).There was no significant difference in the comparison of total occurrence of adverse reactions between the two groups(P>0.05).Conclusion:In the clinical treatment of IBS,using a single colonoscope to introduce bifidobacteria is beneficial for improving gut microbiota levels,it can provide effective assistance for the recovery of intestinal mucosal barrier function,and has high safety.
关键词
单人肠镜/双歧杆菌/肠易激综合征/临床疗效/肠道菌群Key words
Single person colonoscopy/Bifidobacterium/Irritable bowel syndrome/Clinical efficacy/Gut microbiota引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据