To explore the therapeutic effect of Yiai Zhitong powder combined with Tramadol hydrochloride sustained-release tablets on patients with mild to moderate cancer pain of primary liver cancer and the effects on serum liver cancer markers and T cell subsets
Objective:To explore the therapeutic effect of Yiai Zhitong powder combined with Tramadol hydrochloride sustained-release tablets on patients with mild to moderate cancer pain of primary liver cancer and the effects on serum liver cancer markers and T cell subsets.Methods:Sixty in patients with mild to moderate primary liver cancer pain in our hospital from November 2021 to December 2022 were selected and divided into a control group and observation group with 30 cases in each group according to a completely random number method.Both groups were given routine treatment,the control group was given tramadol hydrochloride sustained-release tablets on the basis of routine treatment,and the observation group was given Yiai Zitong powder combined with tramadol hydrochloride sustained-release tablets on the basis of routine treatment,for a total of 10 days.Pain relief(NRS)score,quality of life(QOL-LC)score,serum alpha-fetoprotein(AFP),alpha-fetoprotein anisoplast(AFP-L3),T lymphocyte subsets(CD4+,CD8+),and average dose of Tramadol hydrochloride sustained release tablets at the end of treatment were observed before and after treatment,and clinical efficacy was determined.Results:After ten days of treatment,the total relief rate of clinical pain in the observation group was96.67%higher than that in the control group(73.33%)(P<0.05).QOL-LC score after treatment was higher than that before treatment(P<0.05),and the observation group was better than the control group(P<0.05).After treatment,serum AFP and AFP-L3 levels in the two groups were decreased compared with those before treatment(P<0.05),and the decrease range was greater in observation group(P<0.05).After treatment,serum CD4+ content in the two groups was increased compared with that before treatment(P<0.05),and the increase was more significant in observation group(P<0.05).After treatment,serum CD8+ content in the two groups was decreased compared with before treatment(P<0.05),and the decrease was more significant in observation group(P<0.05).At the end of treatment,the average dose of Tramadol hydrochloride sustained release tablets in observation group was significantly reduced compared with control group,and the difference was statistically significant(P<0.05).Conclusion:For patients with primary liver cancer complicated with mild to moderate cancer pain,external application of Yiai Zhitong powder combined with Tramadol hydrochloride sustained release tablets can improve clinical symptoms,reduce the level of tumor markers,improve patients'immune function,reduce the amount of analgesic drugs,reduce drug side effects,and improve patients'quality of life.It has good clinical efficacy and is worthy of application.
NETL
NSTL
万方数据
维普
