Effects of Danhe Liuwei Dihuang decoction on lipid metabolism and psychological status in postmenopausal patients with NAFLD
Objective:To investigate the effect of Danhe Liuwei Dihuang decoction on lipid metabolism and psychological status in postmenopausal patients with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 68 postmenopausal patients with NAFLD admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from December 2021 to December 2022 were selected and divided into observation group and control group according to the random number table method,with 34 cases in each group.The observation group was given Danhe Liuwei Dihuang decoction,and the control group was given vitamin E soft capsule,2 weeks as a treatment cycle.The liver function,lipid metabolism,estradiol,steatosis and liver fibrosis score,modified Kupperman score,self-rating anxiety scale score(SAS),self-rating depression scale score(SDS)and adverse reactions were compared between the two groups after 6 cycles of treatment.Results:After 6 cycles of treatment,the total effective rate of the observation group was 88.2%,which was higher than 65.6%of the control group(P＜0.05).The observation group was superior to the control group in reducing BMI and waist circumference of postmenopausal NAFLD patients,improving ALT,AST,GGT,TG,TC,HDL,LDL,FFA,E2 levels,reducing CAP,LSM,APRI values,and reducing modified Kupperman score,SAS and SDS scores(P＜0.05).Conclusion:Danhe Liuwei Dihuang Decoction has been proven to be effective in treating postmenopausal NAFLD.It can improve liver function,lipid metabolism,estrogen level,reduce liver steatosis and fibrosis score,and has a certain regulatory effect on the psychological state of postmenopausal NAFLD patients.
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维普
