Impact of Mint3 variations on the incidence and mortality rate of liver cancer in patients with severe liver fibrosis
Objective:To investigate the effect of Mint3 on the progression of liver fibrosis patients to liver cancer .Methods:230 patients with liver fibrosis were monitored for Mint3 expression in liver tissue with HCC as the outcome ,divided into liver cancer group (82 cases) and non liver cancer group (148 cases),with liver cancer death and non death as subgroups .monitor Mint3 levels and analyze the relationship between Mint3 and liver fibrosis,as well as the survival of liver cancer patients .Results:The Mint3 levels in the group with liver cancer and the subgroup with liver cancer death showed an upward trend (P <0.05) during the monitoring period from admission to 36 months,and were both higher than those in the group without liver cancer and the group without liver cancer death (P <0.05).The liver fibrosis indicators and AFP in the group with liver cancer were significantly higher than those in the group without liver cancer (P <0.05).Mint3 was positively correlated with whether liver cancer occurs and whether liver cancer death occurs in patients with liver fibrosis ,liver fibrosis indicators,and AFP (P <0.05),and all of the above indicators were risk factors for liver cancer in patients with liver fibrosis (P <0.05).The AUC value, sensitivity, and specificity of Mint3 in predicting the occurrence of liver cancer and liver cancer -related death in patients with liver fibrosis were high.the survival rate of low-level Mint3 patients with liver fibrosis after liver cancer was higher than that of high -level patients (P = 0.000).Conclusion:Elevated Mint3 levels may promote the progression of liver fibrosis to liver cancer ,and monitoring Mint3 values can help in the early diagnosis and prognosis of liver fibrosis to liver cancer .
NETL
NSTL
万方数据
维普
