Relationship between arterial blood lactate level and hepatorenal syndrome in decompensated cirrhosis
Objective:To explore the relationship between arterial blood lactate concentration and hepatorenal syndrome(HRS)in patients with decompensated cirrhosis.Methods:A total of 54 patients with decompensated cirrhosis who were initially diagnosed and treated from January 2020 to January 2022 were retrospectively analyzed.Arterial blood lactic acid was routinely detected on the 1 st,3 rd,5 th,and 7 th day after admission.According to the presence or absence of HRS,the patients were divided into HRS group and non-HRS group.The baseline characteristics and arterial blood lactate concentration at different time points were compared between the two groups.The correlation between arterial blood lactate and HRS at different time points after admission was analyzed.According to the arterial blood lactate level on the first day of admission,the patients were divided into low lactate group(＜4 mmol/L)and high lactate group(≥4 mmol/L).The liver function and the incidence of HRS were compared between the two groups.According to the level of lactic acid and the occurrence of HRS,the patients were divided into a low-non-HRS group,a high-non-HRS group,a low-HRS group,and a high-HRS group.The 3-month mortality rates of each group were compared.Results:There was no significant difference between the HRS group and the non HRS group in age,sex,body mass index disease etiology and other aspects of the baseline(P＞0.05).On the first,third,fifth,and seventh days after admission,the arterial blood lactate concentration in the HRS group was significantly higher than that in the non HRS group(P＜0.001).On the first,third,fifth and seventh day of admission,the concentration of lactic acid in arterial blood was strongly correlated with HRS(0.6＜r＜0.8,P＜0.001),and the concentration of lactic acid in arterial blood on the first day of admission was strongly correlated with HRS(r =0.871,＜0.001).The incidence of hepatorenal syndrome in the high lactate group was 66.0%higher than that in the low lactate group(P＜0.001).When patients with hepatorenal syndrome complicated with hyperlactatemia,the mortality rate of patients in March sharply increases,reaching as high as 72.7%.Conclusion:High lactate level is an important indicator for early identification of HRS and 3-month mortality risk in patients with liver cirrhosis.
NETL
NSTL
万方数据
维普
