Clinical value of serum macrophage migration inhibitor and cell-free DNA in HBV related acute-on-chronic liver failure patients
Objective:To observe the changes of serum macrophage migration inhibitory factor(MIF)and cell-free DNA(cf-DNA)in hepatitis B virus(HBV)related acute-on-chronic liver failure(ACLF)patients and analyze the clinical value of MIF and cf-DNA in liver failure.Methods:Sixty patients with HBV related ACLF(liver failure group)and 30 healthy subjects(control group)were selected.Clinical data were collected.Serum MIF and cf-DNA levels of each group were detected by kits.The correlation between MIF,cf-DNA and clinical inflammation indexes was analyzed by Pearson or Spearman correlation analysis.Results:Serum MIF and cf-DNA levels were higher in liver failure group compared with control group(P<0.05).MIF was positively correlated with cf-DNA(r =0.482),procalcitonin(PCT)(r = 0.566)and hypersensitive C-reactive protein(hs-CRP)(r =0.285)(P<0.05).The cf-DNA was positively correlated with PCT(r = 0.526)and hs-CRP(r = 0.336)(P<0.05).Conclusion:The serum levels of MIF and cf-DNA in HBV related ACLF patients are increased,and MIF and cf-DNA play important roles in liver failure.
liver failuremacrophage migration inhibitorcf-DNAinflammatory index
万方数据
维普
