A retrospective study on herb-induced liver injury caused by Polygoni Multiflori Radix Praeparata and its proprietary Chinese patent medicine
Objective:Observing the possible incidence of herb-induced liver injury(HILI)caused by Polygoni Multiflori Radix Praeparata,Run-Zao-Zhi-Yang capsules and Bai-Le-Mian capsules in the population receiving traditional Chinese medicine treatment and exploring their risk factors.Methods:A retrospective study was conducted to analyze the possibility of incidence of HILI in patients who used Polygoni Multiflori Radix Praeparata,Run-Zao-Zhi-Yang capsules and Bai-Le-Mian capsules while receiving traditional Chinese medicine treatment in the outpatient clinic of Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine from January 2020 to June 2022.Results:In the outpatient clinic of Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine between January one,2020,and June 30,2022,the possibility of incidence of HILI caused by Polygoni Multiflori Radix Praeparata was 2.64‰.The possibility of incidence of HILI caused by Run-Zao-Zhi-Yang Capsules was 2.40‰.The possibility of incidence of HILI caused by Bai-Le-Mian Capsules was 2.06‰.For patients taking Bai-Le-Mian Capsules,having thyroid disease was a risk factor for the occurrence of HILI(P<0.001).Conclusion:The incidence of HILI caused by Polygoni Multiflori Radix Praeparata and its proprietary Chinese patent medicine is low,and HILI should be properly evaluated for the safe and rational application of traditional Chinese medicine.
herb-induced liver injuryPolygoni Multiflori Radix PraeparataChinese patent medicine
万方数据
维普
