Expression and clinical significance of miRNA-122 in serum of coronary heart disease patients with nonalcoholic fatty liver disease
Objective:To investigate the expression and clinical significance of miRNA-122 in the serum of coronary heart disease patients with nonalcoholic fatty liver disease(NAFLD).Methods:200 coronary heart disease patients who were treated in our hospital from January 2021 to December2022 were selected as the study subjects.They were divided into100 coronary heart disease patients(50.0%)and 100 coronary heart disease patients combined with NAFLD(50.0%)according to whether they were combined with NAFLD.The general clinical data and the expression level of miRNA-122 of patients between the two groups were compared.The independent predictive factors affecting the combination of NAFLD in coronary heart disease patients were obtained by multivariate logistic regression analysis.Focusing on the analysis of the correlation between miRNA-122 and NAFLD in coronary heart disease patients,the relevant nomogram model was established.About100 coronary heart disease patients with NAFLD were divided into high miRNA-122 group(62%)and low miRNA-122 group(38%)according to the median of miRNA-122 in coronary heart disease patients with NAFLD.The correlation between miRNA-122 and clinical indicators in coronary heart disease patients with NAFLD was analyzed.Results:Multivariate logistic regression analysis showed that SYNTAX score,HOMA-IR and miRNA-122 were independent predictors in coronary heart disease patients with NAFLD(P<0.05).A nomograph model of coronary heart disease patients with NAFLD was constructed based on three independent predictors obtained from multivariate analysis:SYNTAX score,HOMA-IR and miRNA-122.The calibration curve of the nomograph model showed that the predicted value of the probability in coronary heart disease patients with NAFLD was in good agreement with the actual observation value(P>0.05).The ROC analysis results showed that the area under the curve(AUC)of SYNTAX score,HOMA-IR and miRNA-122 predicting coronary heart disease patients with NAFLD were 0.775(95%CI:0.721～0.856),0.752(95%CI:0.711～0.813)and 0.822(95%CI:0.784～0.873),respectively,and the maximum AUC predicted by the three factors was 0.918(95%CI:0.878～0.959).The index of triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL),liver hardness,SYNTAX score,C-reactive protein(CRP)and HOMA-IR in the low miRNA-122 group were significantly higher than in the high miRNA-122 group(P<0.05).Conclusion:The nomograph model has a high predictive value for coronary heart disease patients complicated with NAFLD based on SYNTAX score,HOMA-IR and miRNA-122.The coronary heart disease patients complicated with NAFLD who have low expression level of miRNA-122 have a higher degree of liver fibrosis and coronary atherosclerosis.
万方数据
维普
