CT quantitative assessment of the relationship between muscle mass and non-alcoholic fatty liver disease
Objective:To investigate the relationship between muscle mass and different degrees of non-alcoholic fatty liver disease(NAFLD)by computed tomography computed tomography(CT).Methods:A total of 69 patients with abdominal CT scan were divided into normal group,mild NAFLD group,moderate NAFLD Group and severe NAFLD Group by the ratio of liver to spleen(CTL/s).There were 16,21,17 and 14 patients in each group.The CTL/s,abdominal circumference length,diameter of abdominal circumference,area of psoas major muscle,area of erector muscle,area of rectus abdominis muscle,area of oblique and transverse abdominis muscle,volume of abdominal cavity and fat volume of abdominal cavity were measured.To analyze the difference between groups,the correlation between CTL/s and each index,and draw the receiver operating characteristic curve(ROC)to explore the relationship between muscle fat content and different degrees of NAFLD.Results:Compared with the normal control group,NAFLD group and severe NAFLD group,the volume of abdominal cavity and fat in the three groups were significantly lower(P<0.05).There was a negative correlation between erector,rectus abdominis,oblique abdominis and transverse abdominis,abdominal cavity volume(P<0.05).The sensitivity and specificity(AUC≥0.78)in the diagnosis of mild fatty liver in the muscle of spine,rectus abdominis,oblique abdominis,transverse abdominis and abdominal cavity volume.Conclusion:muscle mass loss occurs earlier in the course of early NAFLD than fat accumulation,and CT measurement of muscle mass is of high diagnostic value for mild NAFLD.
万方数据
维普
