摘要
目的:通过CT探讨肌肉含量与不同程度非酒精性脂肪性肝病(NAFLD)的关系.方法:选取69 例腹部CT检查的受试者,通过肝脾比(CTL/S)分为正常组、轻度NAFLD组、中度NAFLD组和重度NAFLD组,每组人数分别为 16、21、17、14 例.测量CTL/S、腹围周长、腹围长径、腰大肌面积、竖脊肌面积、腹直肌面积、腹斜肌与腹横肌面积、腹腔体积、腹腔脂肪体积.分析组间差异、各指标与CTL/S相关性,绘制受试者工作特征曲线(ROC)探讨肌肉脂肪含量与不同程度NAFLD的关系.结果:竖脊肌、腹直肌、腹斜肌与腹横肌、腹腔体积和腹腔脂肪体积均低于正常组、中度NAFLD组和重度NAFLD组,差异有统计学意义(P<0.05).腹围周长、腹围长径、竖脊肌、腹直肌、腹斜肌与腹横肌、腹腔体积呈负相关(P<0.05),竖脊肌、腹直肌、腹斜肌与腹横肌和腹腔体积在诊断轻度NAFLD中具有敏感度和特异度(AUC≥0.78).结论:在早期NAFLD病程进展中肌肉含量减少比脂肪累积发生的更早;CT测量肌肉含量诊断轻度NAFLD具有较高的诊断价值.
Abstract
Objective:To investigate the relationship between muscle mass and different degrees of non-alcoholic fatty liver disease(NAFLD)by computed tomography computed tomography(CT).Methods:A total of 69 patients with abdominal CT scan were divided into normal group,mild NAFLD group,moderate NAFLD Group and severe NAFLD Group by the ratio of liver to spleen(CTL/s).There were 16,21,17 and 14 patients in each group.The CTL/s,abdominal circumference length,diameter of abdominal circumference,area of psoas major muscle,area of erector muscle,area of rectus abdominis muscle,area of oblique and transverse abdominis muscle,volume of abdominal cavity and fat volume of abdominal cavity were measured.To analyze the difference between groups,the correlation between CTL/s and each index,and draw the receiver operating characteristic curve(ROC)to explore the relationship between muscle fat content and different degrees of NAFLD.Results:Compared with the normal control group,NAFLD group and severe NAFLD group,the volume of abdominal cavity and fat in the three groups were significantly lower(P<0.05).There was a negative correlation between erector,rectus abdominis,oblique abdominis and transverse abdominis,abdominal cavity volume(P<0.05).The sensitivity and specificity(AUC≥0.78)in the diagnosis of mild fatty liver in the muscle of spine,rectus abdominis,oblique abdominis,transverse abdominis and abdominal cavity volume.Conclusion:muscle mass loss occurs earlier in the course of early NAFLD than fat accumulation,and CT measurement of muscle mass is of high diagnostic value for mild NAFLD.
基金项目
国家自然科学基金面上项目(82274352)
湖北省自然科学基金创新群体项目(2020CFA023)
维普
万方数据