首页|基于因子-聚类分析的739例Ⅲ期原发性肝癌中医证候研究

基于因子-聚类分析的739例Ⅲ期原发性肝癌中医证候研究

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目的:探讨Ⅲ期原发性肝癌中医证候特点.方法:制定"原发性肝癌中医证候分布调查表",收集739 例Ⅲ期原发性肝癌患者的流行病学及中医四诊信息资料,对患者的流行病学资料进行描述性分析,对症状及体征进行因子分析及聚类分析.结果:Ⅲ期原发性肝癌涉及的病位有肝、脾、肾、胆、胃;病性包括气虚、阴虚、阳虚、热、湿、瘀血、气滞;提取11 个公共因子,聚为4 类时,症状指标分散性良好,证型分布清晰.结论:Ⅲ期原发性肝癌以中老年男性发病率较高,容易出现肝外转移;中医病位主要在肝、脾、胆、肾、胃,病性为本虚标实、虚实夹杂;证候可分为4 个证型,肝肾阴虚证,肝郁脾虚证,脾虚湿困证,肝胆湿热、瘀血阻络证.
The TCM syndromes of 739 patients with stage Ⅲ primary liver cancer based on factor analysis and cluster analysis
Objective:Exploring the characteristics of Traditional Chinese Medicine syndrome distribution in Phase Ⅲ primary liver cancer.Methods:The epidemiologic and Traditional Chinese Medicine(TCM)informational data pertaining to 739 patients diagnosed with Stage Ⅲ primary hepatic carcinoma were amassed via the"Primary Liver Cancer TCM Syndrome Distribution Questionnaire".An analytical descriptive approach was harnessed to scrutinize the patients'epidemiological data,whereas their symptoms and manifestations were examined through factorial analysis and cluster analysis.Results:Stage Ⅲ primary liver cancer involved liver,spleen,kidney,gallbladder and stomach.Diseases include:qi deficiency,yin deficiency,yang deficiency,heat,dampness,blood stasis and qi stagnation;When 11 common factors were extracted and grouped into 4 categories,the symptom indexes were well dispersed and the syndrome types were clearly distributed.Conclusion:The incidence of stage Ⅲ primary liver cancer is higher in middle-aged and elderly men,and it is easy to have extrahepatic metastasis.TCM diseases are mainly located in liver,spleen,gallbladder,kidney and stomach.and The disease is based on deficiency and excess,and the deficiency and excess are mixed.Syndrome can be divided into four syndrome types,include liver and kidney yin deficiency syndrome,liver stagnation and spleen deficiency syndrome,syndrome of spleen deficiency and dampness,syndrome of damp-heat in liver and gallbladder,blood stasis blocking collaterals.

Stage Ⅲ primary liver cancerTCM syndromesFactor analysisCluster analysis

李梅、陈新瑜、黄祎、谭梅傲、刘华宝

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重庆市中医院肝病科 (重庆,400021)

Ⅲ期原发性肝癌 中医证候 因子分析 聚类分析

重庆市科卫联合中医药科研项目青年人才基金全国名中医传承工作室项目全国名中医传承工作室项目

2019ZY3197渝中医202233号渝财社202343号

2024

中西医结合肝病杂志
中国中西医结合学会,湖北中医学院

中西医结合肝病杂志

CSTPCD
影响因子:0.908
ISSN:1005-0264
年,卷(期):2024.34(4)
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