Diagnostic value of the PIVKA-Ⅱ,GGT,GPR,GLR and PLR for the development of hepatitis B virus related primary hepatocellular carcinoma
Objective:To explore the changes of vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),γ-glutamyl transpeptidase(γ-GGT),γ glutamyl transpeptidase to platelet ratio(GPR),γ glutamyl transpeptidase to lymphocyte count ratio(GLR),platelet to lymphocyte count ratio(PLR)in patients with different liver diseases caused by hepatitis B virus(HBV)infection,as well as the predictive value of the primary and combined detection in hepatitis B associated primary liver cancer.Methods:A retrospective analysis was performed on 241 HBV-related liver disease treated in our hospital between January 2020 and December 2022,including 83 patients with chronic hepatitis B(CHB),82 patients with hepatitis B-related liver cirrhosis(HBV-LC),76 patients with primary liver cancer related to hepatitis B(HBV-HCC).At the same period,and 81 cases of health check-up personnel were selected as the normal control group(NC).The expression differences of PIVKA-Ⅱ,GGT,GPR,GLR and PLR and the positive rate of PIVKA-Ⅱ and GGT in the four groups were statistically analyzed;Pearson linear correlation analysis was performed to determine the correlation between GLR,GPR,PLR and serum PIVKA-Ⅱ,GGT in HBV-HCC group;ROC curve was used to analyze the diagnostic value of PIVKA-Ⅱ,GGT,GLR,GPR and PLR alone and in combination with HBV-HCC.Results:The expression levels of PIVKA-Ⅱ,GGT,GLR and GPR in CHB group,HBV-LC group and HBV-HCC group increased successively,and the expression levels of GGT,GLR and GPR were statistically significant compared with the two groups(P<0.05).The PIVKA-Ⅱ expression level of HBV-HCC group was higher than that of CHB group and HBV-LC group,and the differences were statistically significant(P<0.05).The expression levels of PIVKA-Ⅱand PLR in CHB and HBV-LC groups were lower than NC group.The differences were statistically significant(P<0.05).The positive rates of PIVKA-Ⅱ and GGT in HBV-HCC group were more than 50%.There was a positive correlation between GLR,GPR,PLR and PIVKA-Ⅱ,GGT in HBV-HCC group,The diagnostic sensitivity,AUC and Youden index of PIVKA-Ⅱ,GGT,GLR and GPR combined detection were higher than those of PIVKA-Ⅱ,GGT,GLR,GPR and PLR alone detection,and the specificity of GGT,GLR and GPR combined detection reached 95.06%.Conclusion:PIVKA-Ⅱ,GGT,GPR,GLR and PLR have certain differences in patients with different liver diseases caused by HBV infection.The combined detection of PIVKA-Ⅱ,GGT,GPR and GLR is helpful for early diagnosis of HBV-HCC.
hepatitis B-related primary liver cancerPIVKA-ⅡGGTGLRGPRPLRdiagnostic value
NETL
NSTL
万方数据
维普
