Changes in liver stiffness values and their relationship with liver fibrosis in patients with wilson's disease of different traditional Chinese medicine syndrome types
Objective:To investigate the differences in liver stiffness measurement(LSM)and fibrosis indices with Wilson's disease(WD)of different Chinese medicine certificates and their relationship.Methods:110 patients with WD who were admitted to our hospital from February 2021 to April 2023 were retrospectively collected.The index cluster analysis was used to draw the cluster map for TCM syndrome types.Simple correspondence was used to analyze the correspondence between TCM syndrome type and ADL degree.The general clinical data,US parameters and liver fibrosis related indexes of different TCM syndromes were compared to explore the relationship among LSM,liver fibrosis and TCM syndromes distribution.Results:The traditional Chinese medicine syndromes of WD patients are mainly dampness-heat intrinsic syndrome(59 cases,53.64％),followed by phlegm-stasis interlocking syndrome(43 cases,39.09％),liver-kidney Yin deficiency syndrome(5 cases,4.54％)and spleen-kidney Yang deficiency syndrome(3 cases,2.73％).The syndrome of phlegm and blood stasisis is inclined to grade 0-Ⅰ,the syndrome of dampness-heat inclined to grade Ⅱ,and the syndrome of liver and kidney Yin deficiency is inclined to grade Ⅲ-Ⅳ,Spleen-kidney Yang deficiency syndrome is in the middle of two-dimensional proj ection map,which did not deviate to a certain grade of WD lesion degree.The levels of LSM in dampness-heat intrinsic syndrome were significantly lower than those in phlegm-stasis interlocking syndrome,liver-kidney Yin deficiency and spleen-kidney Yang deficiency syndrome(P＜0.05).Serum hyaluronic acid(HA)and type Ⅳ collagen(Ⅳ-C)were higher in liver-kidney yin deficiency and spleen-kidney yang deficiency than in damp-heat and phlegm-stasis interlocking(P＜0.05).There was no significant difference of Type Ⅲ procollagen amino terminal peptide(PⅢNP)and Laminin(LN)levels in 4 groups(P＞0.05).LSM was positively correlated with HA,C-Ⅳ in every TCM type except in spleen-kidney Yang deficiency syndrome.Conclusion:Serological indices combined with LSM can better assessment the degree of hepatic fibrosis.
NETL
NSTL
万方数据
维普
