Correlation between elevated bilirubin and prognosis in patients with drug-induced vanishing bile duct syndrome
Objective:To observe the correlation between the elevation of bilirubin in the course of the disease and the pathological characteristics and prognosis of the patients with drug-induced vanishing bile duct syndrome(D-VBDS).Methods:Forty-five patients with D-VBDS diagnosed by liver biopsy were retrospectively observed.According to whether they had elevated bilirubin during the course of the disease,they were divided into two groups.The clinical data,medication history,liver biochemical indicators,pathological morphological characteristics and prognosis of the two groups were observed,and the correlation between elevated bilirubin and pathological morphological characteristics and prognosis of the two groups were compared and analyzed.Results:There was no significant difference in the average age of onset,gender composition and course of disease between the normal bilirubin group and the high bilirubin group(P＞0.05).Chinese medicine or Chinese patent medicine accounted for the highest proportion in the two groups(39.3％v 40.0％).There were no statistically significant differences in other symptoms and signs between the two groups except for the yellow skin and scleral staining(P＞0.05).The TBil,DBil,ALP,GGT,TBA and CHOL in the high bilirubin group were significantly higher than those in the normal bilirubin group(P＜0.05).The scores of bile pigment deposition,bile thrombosis of bile capillaries and foam-like cells in the hyperbilirubinemia group were higher than those in the normal bilirubin group,and there was no significant difference in other pathological morphology scores(P＞0.05).Bile duct hyperplasia,portal inflammation,fibrosis,and chronic cholestasis are the pathological morphological changes related to the prognosis.There was no statistically significant difference in the prognosis of the two groups(P＞0.05).Conclusion:Elevated bilirubin is not the main factor affecting the prognosis of patients with D-VBDS.
vanishing bile duct syndrome,drug-inducedbilirubin levelsprognosticpathological feature
NETL
NSTL
万方数据
维普
