Application value of MSCT combined with serum CCNA2 and AFP in the differential diagnosis of cirrhosis nodule and hepatocellular carcinoma
Objective:To explore the application value of multi-slice spiral computed tomography(MSCT)combined with serum cyclin A2(CCNA2)and alpha-fetoprotein(AFP)in the differential diagnosis of cirrhosis nodule and hepatocellular carcinoma.Methods:A total of 104 patients pathologically confirmed in the hospital were enrolled between January 2019 and January 2022,All underwent abdominal MSCT plain scan and enhancement scan to detect levels of serum CCNA2 and AFP.The imaging characteristics of MSCT in patients with cirrhosis nodules and hepatocellular carcinoma were analyzed.Taking pathological results as the golden standard,the consistency of MSCT in the differential diagnosis of hepatocellular carcinoma and cirrhosis nodule was compared.The levels of serum CCNA2and AFP were compared between the cirrhosis nodule group and the hepatocellular carcinoma group.The application value of MSCT combined with serum tumor markers in the differential diagnosis of cirrhosis nodules and hepatocellular carcinoma was detected by receiver operating characteristic(ROC)curves.Results:In the 104 patients,pathological examination showed that there were 70 cases in the cirrhosis nodule group and 34 cases in the hepatocellular carcinoma group.Taking pathological results as the golden standard,the sensitivity and specificity of MSCT in the differential diagnosis of hepatocellular carcinoma were 76.47％and 75.71％(Kappa=0.493).The levels of serum CCNA2 and AFP in the hepatocellular carcinoma group were significantly higher than those in the cirrhosis nodule group(P＜0.05).The results of ROC curves analysis showed that area under the curve(AUC)values of MSCT,serum CCNA2,and AFP for predicting hepatocellular carcinoma were 0.886,0.836,and 0.775,respectively.The AUC and sensitivity of MSCT combined with serum CCNA2 and AFP for predicting hepatocellular carcinoma were 0.902 and 82.86％(P＜0.05).Conclusion:MSCT combined with serum CCNA2 and AFP has high clinical application value in the differential diagnosis of cirrhosis nodules and hepatocellular carcinoma.
万方数据
维普
