Analysis of the relationship between serum iron,CA19-9/GGT ratio and microv-ascular invasion,postoperative recurrence and prognosis of hepatocellular carcinoma
Objective:To investigate the relationship between serum iron,carcinoembryonic antigen 19-9(CA19-9)/gamma-glutamyltranspeptidyase(GGT)ratio and microvascular invasion(MVI),postoperative recurrence and prognosis of hepatocellular carcinoma(HCC).Methods:A total of 80 patients with hepatocellular carcinoma(HCC group)and 53 healthy volunteers(control group)admitted to our hospital from March 2020 to March 2023 were selected,and the patients were divided into MVI group(46 cases)and non-MVI group(34 cases)according to whether MVI occurred.The serum iron and CA19-9/GGT ratio were detected before the operation,and postoperative recurrence and overall survival(OS)were analyzed by regular postoperative follow-up.The patients were divided into the recurrence group(26 cases)and non-recurrence group(54 cases)according to recurrence.The value of serum iron and CA19-9/GGT in preoperative diagnosis of MVI was analyzed by the receiver operating characteristic(ROC)curve.The relationship between serum iron,CA19-9/GGT ratio and MVI,postoperative recurrence,and prognosis of hepatocellular carcinoma was analyzed.Results:The serum iron and CA19-9/GGT ratios in HCC group were higher than those in control group(P＜0.05).And the serum iron and CA19-9/GGT ratios in patients with intrahepatic metastasis,TNM stage Ⅲ and poorly differentiated hepatocellular carcinoma were higher than those without intrahepatic metastasis,TNM stage Ⅰ～Ⅱ and high school differentiation(P＜0.05).The serum iron and CA19-9/GGT ratios in the MVI group were higher than those in non-MVI group(P＜0.05),and serum iron and CA19-9/GGT ratios in the relapsed group were higher than those in non-relapsed group(P＜0.05).The cut-off values of MVI before serum iron and CA19-9/GGT diagnosis were 56.98μmol/L and 2.53,respectively,the area under the curve was 0.767 and 0.882,and the combined diagnosis was 0.934,which were higher than those for single diagnosis(Z=3.498,2.303,P＜0.05).The OS survival rate of patients with high serum iron levels and high CA19-9/GGT ratio was lower than that of patients with low serum iron levels and low CA19-9/GGT ratio(P＜0.05).TNM stage Ⅲ,high serum iron level,and high CA19-9/GGT ratio were risk factors for poor prognosis in HCC patients(P＜0.05).Conclusion:The increase of serum ferrate and CA19-9/GGT ratio in patients with hepatocellular carcinoma is related to preoperative MVI,postoperative recurrence,and poor prognosis.
hepatocellular carcinomamicrovascular invasionrecurrenceprognosisironcarcinoembryonic antigen 19-9/gamma-glutamyl transpeptidase ratio
万方数据
维普
