Effects of anxiety and depressive symptoms on prognosis and immune response in patients with primary liver cancer
Objective:To observe the effects of anxiety and depression on the prognosis and cytokines of primary liver cancer(HCC),and to explore its mechanism.Methods:From September 2021 to June 2022,patients with stage Ⅱ and Ⅲa primary liver cancer who had achieved Complete Response(CR)or Partial Response(PR)after comprehensive interventional therapy for≥6 menstrual periods were included.According to the Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),they were divided into anxiety depression group and non-anxiety depression group(exposed group and non-exposed group).The 1-year disease control rate was compared between the two groups.The factors related to anxiety and depression were screened by Logistic regression analysis.Plasma was collected from patients,and relevant cytokines were detected by high-throughput suspension chip technology to analyze the effect of anxiety and depression on immunity in patients with liver cancer.Results:The 1-year disease control rate of the anxiety-depression group was significantly lower than that of the anxiety-depression group(P＜0.05).Neutrophil count and C-reactive protein(CRP)were correlated with adverse mood in patients with liver cancer(P＜0.05).Cytokine results showed that the plasma cytokine content of MIF,IL-8,CCL25,IL-16,CXCL6,CXCL13,CCL21,CXCL2,CXCL10,CX3CL1,CCL2 and CCL3 in exposed group was significantly higher than that in non-exposed group,and CCL22 was significantly lower than that in non-exposed group.The results showed that MIF,IL-6,CXCL5,CXCL9,IL-8,CCL23,IL-10,IL-4,CCL2 and GM-CSF were significantly increased in exposed group,but significantly decreased in non-exposed group,and CXCL12 was decreased in exposed group but increased in non-exposed group.The intersection factors were MIF,IL-8 and CCL2.Conclusion:Negative emotions affect the prognosis of patients with liver cancer,and the interaction between emotions and inflammatory factors may affect the prognosis of patients through the regulation of MIF,IL-8 and CCL2 immune-related cytokines.
NETL
NSTL
万方数据
