A study on traditional Chinese medicine syndromes,expression of epstein-barr virus capsid antigen IgA antibodies,clinical characteristics,and pathological staging in patients with primary biliary cholangitis
Objective:Analyze the Traditional Chinese Medicine(TCM)syndrome types and the expression of Epstein-Barr Virus(EBV)viral capsid antigen IgA antibodies(EB VCA-IgA)in patients with Primary Biliary Cholangitis(PBC)to understand the impact of different syndrome types and EBV infection on the condition of PBC patients and their relationship with pathological staging.Methods:A total of 87 patients diagnosed with PBC and admitted to the Infectious Disease Department of Jiangsu Provincial Hospital between December 2019 and June 2022 were analyzed.The symptoms and signs of the patients were collected for syndrome differentiation and classification.Concurrently,liver biopsy for histological examination and comprehensive laboratory tests,including detection of serum Epstein-Barr Virus(EBV)related antibodies,were performed.Patients were categorized into EB VCA IgA(+)group and EB VCA IgA(-)group based on the positive expression of serum EB VCA-IgA.Differences in clinical and pathological data between the two groups were compared.Additionally,the relationship between the TCM syndrome types of the patients and the positive expression of serum EB VCA-IgA,as well as the liver pathological staging,was analyzed.Results:In the Qi Yin deficiency syndrome group,the proportion of patients with advanced liver pathology and positive expression of EB VCA IgA was significantly higher than that in the Liver Depression Spleen Deficiency syndrome group(P＜0.05).Basic clinical data between EB VCA IgA(+)and EB VCA IgA(-)groups showed statistically significant differences in serum IgG and IgA levels,with elevated levels in the EB VCA-IgA(+)group(P＜0.05).The proportion of patients with advanced liver pathology and higher inflammation activity grade(G3 group)was higher in the EB VCA-IgA(+)group,with statistically significant differences(P＜0.05).Multifactor logistic regression analysis suggested that the TCM syndrome type of Qi Yin deficiency,advanced liver pathology stage,and high levels of IgG and IgA were independent risk factors affecting the positive expression of EB VCA-IgA in PBC patients.Conclusion:Patients with qi and yin deficiency syndrome have more severe liver inflammation and fibrosis,and are more likely to be co-infected with Epstein-Barr virus.Qi and yin deficiency syndrome,progressive liver pathology,high IgG and high IgA levels are independent risk factors for positive EB VCA-IgA expression in PBC patients.
Epstein-Barr Virus infectionEpstein-Barr Virus capsid antigen immunoglobulin A antibodyprimary biliary cirrhosistraditional Chinese medicine syndrome typespathological stage
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