Clinical effects of ultrasound-guided MWA combined with anhydrous alcohol in the treatment of patients with small primary hepatocellular carcinoma
Objective:The aim of this study was to explore the clinical effects of ultrasound-guided percutaneous microwave ablation(MWA)combined with anhydrous alcohol in the treatment of patients with small primary hepatocellular carcinoma.Methods:A retrospective study was conducted.A total of 284 patients with small primary hepatocellular carcinoma were admitted to the hospital between June 2020 and June 2023.They were selected as the study subjects and divided into the control group(n=181,ultrasound-guided MWA)and the observation group(n=103,ultrasound-guided MWA combined with anhydrous alcohol treatment)according to different treatment methods.Therapeutic effects,liver function,complications,and prognosis in the two groups were comparatively analyzed.Results:The complete ablation rate in the observation group(92.23%)was significantly higher than that in the control group(72.38%)(P＜0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBil)in the two groups were comparable before treatment(P＞0.05).One week after treatment,the levels of ALT,AST,and TBil in both groups increased(P＜0.05),but there was no significant difference between the groups(P＞0.05).One month after treatment,there was no significant difference in the levels of ALT,AST,and TBil compared to those before treatment(P＞0.05).The incidence of complications in the observation group was lower than that in the control group,but the difference was not statistically significant(P＞0.05).As of December2023,6 of 95 patients in the observation group who obtained complete ablation experienced recurrence,with a recurrence rate of 6.32%.The progression free survival(PFS)of the observation group was(13.55±4.03)months.About 15 of 131 patients in the control group who obtained complete ablation experienced recurrence,with a recurrence rate of 11.45%.The PFS of the control group was(12.69±3.39)months.There was no statistically significant difference in recurrence rate between the two groups(χ2=1.722,P=0.189).Kaplan-Meier survival analysis results showed that there was no statistically significant difference in PFS between the two groups(χ2=1.616,P=0.204).Conclusion:Applying ultrasound-guided MWA combined with anhydrous alcohol in the treatment of patients with small primary hepatocellular carcinoma can significantly improve the complete ablation rate,without causing serious liver damage and with high safety.The treatment can be used for clinical promotion.
万方数据
维普
