Analysis of the experience of Professor Lv Wenliang in the treatment of non-alcoholic fatty liver disease based on real-world research by data mining
Objective:Analyzing Clinical Medication Practices of Professor Lv Wenliang for Treating Non-Alcoholic Fatty Liver Disease(NAFLD).Methods:Based on real-world medical data,we collected and collated 1,383 prescriptions of Professor Lv Wenliang for the treatment of NAFLD in the outpatient clinic of Guang'anmen Hospital of the China Academy of Traditional Chinese Medicine(CATCM)from 1 January 2017 to 23 May 2023 and used Excel to establish a normalized and standardized database for the clinical information,and then with the help of SPSS Statistics 20.0 and SPSS Modeler 18.0 software for association rule analysis and cluster analysis of HF drugs.Results:A total of 1,383 prescriptions were included,involving 355 flavors of drugs,of which the top 10 drugs in terms of frequency were:Paeonia lactiflora,Radix Bupleurum Chinense,Herba Leonurus,Radix Astragali,Lotus leaf,Rhizoma Atractylodis Macrocephalae,Poria cocos,Radix Angelicae Sinensis,Glycyrrhiza Uralensis,and Herba Taraxacum Chinense,which are mostly warm,calm,and cold in nature,with bitter,sweet,and pungent flavors;they are mainly found in the meridians of the liver,lungs,stomach,and spleen.There were 12 drug combinations such as"Xiang Fu → Angelica sinensis,Neem Ziziphi → Xiang Fu,Huang Lian → Ze Xie,Cang Zhu → Ze Xie,"and 3 cluster formulas such as"Tarragon grass,Qian Cao,Yin Chen,Lotus Leaf,Chicken Nei Jin,turmeric,Chinese yam,and Semen Coix lacryma"were obtained from the cluster analysis.Conclusion:Professor Lv believed that"dampness,heat,stasis,phlegm,deficiency,and depression"are the main pathological factors of NAFLD,and that the main treatment principle is to strengthen the spleen and dredge the liver,clear dampness,heat,and activate blood,and to emphasize the combination of attacking and tonifying,combining cold and warmth,combining sweetness and bitterness,regulating qi and blood,and adding and subtracting according to the symptom,and emphasizing the principle of peacefulness and the importance of harmony.
Nonalcoholic fatty liver diseasethe experience of Qichuang scholarrule of medicine in Chinese medicine
万方数据
维普
