首页|基于数据挖掘和隐结构探析原发性肝癌的中药组方用药规律

基于数据挖掘和隐结构探析原发性肝癌的中药组方用药规律

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目的:基于数据挖掘和隐结构探析原发性肝癌的中药组方用药规律.方法:收集湖北省中医院 2016 年 11 月至 2022年3 月原发性肝癌患者住院诊疗信息,建立数据库,进行数据分析.结果:纳入1396 个处方,涉及357 味中药,58 味高频中药,9 条关联规则,9 个综合聚类.结论:原发性肝癌主以扶正补虚,即扶正补虚应贯穿本病全过程,且非单一用药,而是兼备补气、养血、滋阴、温阳.辅以攻邪抗癌,即治气、痰、湿、瘀、毒等,其基本治法包括行气解郁、化痰利湿、活血化瘀、清热解毒等.此外,临证中存在阳虚、寒凝等证型,值得进一步探索和讨论.
Exploration on the prescription regularity of traditional Chinese medicine for the treatment of primary liver cancer based on latent structure combined with data mining
Objective:Exploration on the prescription regularity of traditional Chinese medicine(TCM)for the treatment of primary liver cancer based on latent structure combined with data mining.Methods:Data were collected from inpatient clinical records of PLC patients at Hubei Provincial Hospital of Traditional Chinese Medicine between November 2016 and March 2022.A database was established for data analysis.Results:A total of 1,396 prescriptions were included,involving 357 different Chinese herbs,58 of which were high-frequency herbs.Additionally,9 associated rules and 9 comprehensive clusters were generated.Conclusion:The primary treatment approach for PLC involves tonifying the body's vital energy and reinforcing deficiencies.This approach should be integrated throughout the entire disease progression and should not rely solely on a single medication.Instead,the treatment regimen should encompass Qi tonification,blood nourishment,Yin enrichment,and Yang warming.Additionally,anti-cancer strategies targeting pathogenic factors,including Qi stagnation,phlegm,dampness,stasis,and toxins,are essential.Fundamental therapeutic methods encompass promoting Qi circulation,resolving depression,transforming phlegm and dampness,activating blood circulation,dissolving stasis,clearing heat,and detoxifying.Furthermore,specific TCM syndromes such as Yang deficiency and cold congelation observed in clinical practice warrant further exploration and discussion.

primary liver cancerlatent structureassociation rulesdata miningprescription regularity

宋幸铃、陈成笙、周亚娜、田晓霞、杨槟旭、沈心海

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成都市中西医结合医院/成都市第一人民医院(四川 成都,610016)

广西中医药大学第一附属医院

湖北省中医院

湖北中医药大学附属医院

湖北省中医药研究院

湖北中医药大学

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原发性肝癌 隐结构 关联规则 数据挖掘 用药规律

湖北省自然科学基金项目湖北中医药大学"十四五"优秀学科团队建设项目省级区域中医医疗综合中心建设专项湖北中医药大学大学生创新创业训练计划省级项目

2022CFB542中医校[2022]90号P-20230901-12295432-10050308

2024

中西医结合肝病杂志
中国中西医结合学会,湖北中医学院

中西医结合肝病杂志

CSTPCD
影响因子:0.908
ISSN:1005-0264
年,卷(期):2024.34(10)