Molecular mechanisms and clinical advances of traditional Chinese medicine in regulating the immune microenvironment of liver cancer
Liver cancer ranks as the third leading cause ofcancer-related mortality globally,with immune evasion playing a pivotal role in the limited efficacy of immunotherapy in its treatment.The urgent need for effective and precise strategies to optimize immunotherapy for hepatocellular carcinoma (HCC)has garnered significant attention.The traditional Chinese medicine (TCM)concept of "supporting the healthy energy and eliminating pathogenic factors"closely aligns with the principles of modern tumor immunotherapy.Extensive research highlights the remarkable role of TCM in enhancing the immune microenvironment,boosting therapeutic efficacy,and reducing toxicity in HCC.Active compounds such as icariin and astragalus polysaccharides improve the immune microenvironment by modulating the cell cycle and enhancing CD8?T cell and natural killer (NK)cell activity.Moreover,TCM formulations,including Yangyin Fuzheng Jiedu Decoction and Dahuang Zhechong Pills,demonstrate immunomodulatory effects by mitigating CD8?T cell exhaustion,enhancing NK cell cytotoxicity,and regulating macrophage polarization,thus effectively suppressing immune evasion.When incorporated into combination therapies,TCM exhibits promising immunoregulatory potential,making it a compelling candidate for advancing immunotherapy in HCC.
traditional Chinese medicinehepatocellular carcinomaimmunomodulationimmune microenvironment
万方数据
维普
