Effects of Ganzhiling Decoction combined with glutathione on liver function,blood lipid and oxidative stress indexes in patients with non-alcoholic fatty liver disease
Objective:Investigation of the effects of a self-developed hepatic lipid-reducing decoction combined with glutathione on liver function,lipid profiles,and oxidative stress markers in patients with non-alcoholic fatty liver disease (NAFLD).Methods:Ninety-eight patients with NAFLD admitted to our hospital from October 2019 to October 2022 were selected as subjects and divided into two groups by envelope method:glutathione group (n=48)was given glutathione treatment,and the self-designed prescription group (n=48)was given self-designed Ganzhiding decoction combined with glutathione treatment.Syndrome score and fatty liver score were evaluated between the two groups.Differences in liver function,blood lipid and oxidative stress indexes were detected between the two groups,and the efficacy of abdominal B-ultrasound was analyzed.Results:The scores of traditional Chinese medicine syndromes and fatty liver in the self formulated formula group and glutathione group were significantly lower than before treatment,and the scores of traditional Chinese medicine syndromes and fatty liver in the self formulated formula group were significantly lower than those in the glutathione group (P<0.05 ).The levels of GGT,ALT,AST,and ALP in the self formulated formula group and glutathione group were significantly lower than before treatment,and the levels of GGT,ALT,AST,and ALP in the self formulated formula group were significantly lower than those in the glutathione group (P<0.05).The levels of SOD and T-AOC in the self formulated formula group and glutathione group were significantly higher than before treatment,and the levels of SOD and T-AOC in the self formulated formula group were significantly higher than those in the glutathione group (P<0.05);The MDA levels in the self formulated formula group and the glutathione group were significantly lower than before treatment,and the MDA levels in the self formulated formula group were significantly lower than those in the glutathione group (P<0.05).The HDL-C levels in the self formulated formula group and the glutathione group were significantly higher than before treatment,and the HDL-C levels in the self formulated formula group were significantly higher than those in the glutathione group (P<0.05 );The levels of TG,TC,and LDL-C in the self formulated formula group and glutathione group were significantly lower than before treatment,and the levels of TG,TC,and LDL-C in the self formulated formula group were significantly lower than those in the glutathione group (P<0.05 ).The total effective rate of the self-made formula group was 91.67％(44/48),which was higher than 75.00％(36/48)of the glutathione group (P<0.05). Conclusion:Ganzhiling Decoction combined with glutathione in the treatment of NAFLD can reduce oxidative stress,regulate blood lipids,improve liver function and improve curative effect.
Ganzhiling decoctionglutathionenonalcoholic fatty liver diseaseoxidative stressblood fatliver function
万方数据
维普
