Exploring the medication patterns in traditional Chinese medicine for the treatment of alcoholic cirrhosis based on data mining
Objective:Data mining and complex network analysis systems was used to identify and summarize the patterns of Traditional Chinese Medicine prescriptions for the treatment of alcoholic cirrhosis.Methods:Eight databases including CNKI,SinoMed,PubMed,Embase,Medline,Cochrane,VIP and WanFang were screened out to retrieve all the clinical trials of TCM compound prescriptions in the treatment of alcoholic cirrhosis (AC)from the establishment of database to October 2023,and then statistically analyzed the drug frequency,attribution,and drug association rules.Results:A total of 103 studies were included,involving 186 traditional Chinese medicine (TCM) herbs,with 5 core herbs identified.The treatment of AC with TCM primarily utilizes the Four Natures,focusing on mild cold,warmth,and neutrality.The Five Flavors are mainly sweet,bitter,and pungent,while the meridian tropism predominantly targets the spleen and liver meridians.Nine main compatibility patterns of commonly used herb pairs were identified,with the core formula consisting of Poria,Atractylodes,Salvia miltiorrhiza,Astragalus,and Bupleurum.Conclusion:The findings suggest that TCM treatment for alcoholic cirrhosis focuses on addressing the core pathogenesis of liver qi stagnation,spleen deficiency,water retention,and the imbalance between deficiency and excess.The central therapeutic approach emphasizes strengthening the spleen and regulating the liver,integrating strategies such as tonifying qi,supporting the body's upright energy,strengthening the spleen,resolving dampness,and promoting liver qi circulation.Network pharmacology analysis indicates that the core prescription may exert its effects by inhibiting alcohol-induced activation of apoptotic,oxidative stress,and inflammatory pathways.This results in reduced liver inflammation,improved blood rheology and hemodynamics,vascular protection,and the prevention of liver fibrosis.
data miningalcoholic cirrhosisChinese medicineformula formation rulesnetwork pharmacology
万方数据
维普
